Keep in mind that after you take a collagen supplement, your digestive system breaks it down into amino acids. Supplements that are fat soluble, like vitamins A, D, E, and K, should be taken in moderation or at low doses, because they are more likely to build up in your body. Regrettably, anyone on a vegan or stringent vegetarian diet plan can not take collagen supplements due to the fact that its always sourced from some kind of pet item. Some medications can potentially harm your kidney function. Creatine a common supplement for bodybuilders and other athletes can increase blood creatinine levels. As you age, your existing collagen breaks down, and it gets harder for your body to produce more. Written by Hannah Marchese Updated on June 24, 2021. People take this when they have very high triglyceride levels or a high risk for heart disease. A high creatinine level on a blood test can be a sign of decreased kidney function or kidney disease. These include cephalexin (Keflex), cefuroxime (Ceftin), and cefaclor (Ceclor). Further, a variety of other lifestyle factors can also interfere with production, including excess alcohol intake, lack of sleep, inactivity, and UV exposure. Collagen can be found in lots of kinds, yet the vast majority in your body contains kinds I, II and also III. Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells. Allon M, Litovsky SH, Tey JCS, Sundberg CA, Zhang Y, Chen Z, Fang Y, Cheung AK, Shiu YT. Clinical Pharmacology and Therapeutics. Creatinine is a normal waste product that the body produces every day. It also has a role in hormone production. Collagen supplements get a lot of buzz for their potential to plump skin and protect joints (alas, the jury seems to be out on both perks, per the Mayo Clinic) but as with any product, you have to ask: Is there a downside? Keeping kidneys safe: Smart choices about medicines. Trademarks, brands, logos, and copyrights are the property of their respective owners. For people with knee osteoarthritis, collagen supplements might act as a mild pain reliever and improve joint function. The resulting stones can be wider than your ureter, which is the tube that drains urine from your kidneys down to your bladder. Thats where collagen supplementation comes into play. 2. Annu Rev Physiol 80:309326 Kidney failure (ESRD) causes, symptoms, & treatments. Genes Dev 19:10931104 An official website of the United States government. Creatine supplements are used by athletes and fitness enthusiasts to assist in muscle growth and increase short-term endurance. A high protein diet, however, can bring about high creatinine levels as well. Your kidneys are responsible for eliminating the majority of this waste product, so blood creatinine levels are frequently used as . GoodRx is not sponsored by or affiliated with any of the third-party brands identified. Journal of Atherosclerosis and Thrombosis: The results of the present study indicate that CTP contributes to the prevention and treatment of atherosclerosis in healthy humans., A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial., Journal of Oral and Maxillofacial Pathology, : The role of collagen in bone strength., : Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study., By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Healthier Alternatives to Collagen Powder, Becoming a Vegetarian: Foods to Choose From, Proline: found in egg whites, dairy, cabbage, mushrooms, and asparagus, Glycine: found in pork skin, chicken skin, and gelatin, and a variety of other protein-rich foods, Vitamin C: found in citrus fruits and bell peppers, Zinc: found in beef, lamb, pork, shellfish, chickpeas, lentils, beans, milk, cheese, and various nuts and seeds, Copper: found in organ meats, cocoa powder, cashews, sesame seeds, and lentils. When Is The Best Time To Take Creatine And Collagen Together? Skin anti-aging strategies. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/, Collagen Benefits: The Journal of Clinical and Aesthetic Dermatology. Journal of International Medicine. GoodRx provides no warranty for any information. Here are some actions to comply with when trying to find a top quality collagen supplement. Several factors can cause high creatinine levels. [5] Low-intensity exercises include things like jogging, jumping rope, or swimming. Theres also a chance it could be contaminated with pesticides, bacteria, or other substances. And this may elevate your creatinine blood test even though your kidneys are working perfectly fine. However, their decision will depend on someones muscle mass and certain other factors, such as age, sex, and hydration levels. High-sugar nutritional supplements, especially supplements that contain fructose, can cause an increase in uric acid levels. Can dehydration cause creatinine to rise? These include: Pyrimethamine (a medication to treat parasites), Aloxiprin (a salicylate drug used in some types of arthritis), High doses of prednisone (a steroid used in many different conditions). Research shows that creatine is best taken after your workout for maximizing muscle and strength gains. One small study found that men who took collagen peptide supplements during a 12-week strength training program saw more increases in muscle mass and strength than those who . By providing your email address, you agree to receive emails containing coupons, refill reminders and promotional messages from GoodRx. (2016). Collagen Complicated offers easy-to-digest hydrolyzed collagen peptides. This is especially true if you have a history of kidney problems. Thats one reason you should tell your doctor before taking any type of supplement. If your blood test shows a creatinine level above normal range, there are many possible explanations for this. One of the most common reasons your healthcare provider might call you for an abnormal lab result is a high creatinine level. Bovine collagen originates from cows preferably grass-fed cows. If you are highly active or have specific issues you are trying to address, then more collagen is completely fine. Collagen supplements can have a different effect on everyone, but it is widely reported to be a miracle worker when it comes to your skin, hair, nails, and joints. WebMD does not provide medical advice, diagnosis or treatment. Nabumetone (Relafen). Marine Collagen protein bars formulated as a powerful beauty supplement and delicious snack. Therefore those that exercise regularly often have raised creatinine levels in routine blood tests. An untreated kidney infection can damage the kidneys, and, in extreme cases, it can even cause kidney failure. Collagen is an impressive construction product. Collagen is a naturally occurring protein in the body that keeps your connective tissues (including muscles, tendons, ligaments, and cartilage) strong and resilient. Please seek medical advice before starting, changing or terminating any medical treatment. muscle growth) in all healthy young populations. So if you have an elevated creatinine level, its important to talk to your provider about whether this could be a sign of kidney disease. If the kidney stone is big enough to obstruct urine flow, the pain is severe, says Dr. Isreb. To avoid overtaxing your system, only exercise for 20-30 minutes at a time. There are lots of studies which demonstrate creatines ability to improve physical performance. Many people take 1-2 tablespoons of collagen powder per day. The extracellular matrix component collagen is widely expressed in human tissues and participates in various cellular biological processes. Some of them can interfere with the creatinine blood test. The very same may be true for collagen supplements, yet sadly, theres no sign of what would certainly make up too much. Theres likewise no proof that collagen poisoning is a worry if you adhering to dosing guidelines. Bookshelf That being said, you should always consult your doctor if you are unsure about a supplement and how it could affect your body. *These statements have not been evaluated by the Food and Drug Administration. However, recent findings indicate that the natural pore structure of collagen fibers is sufficient to induce the inappropriate differentiation of stem cells and thereby exacerbate renal fibrosis and vascular calcification. People may experience the following symptoms: Lupus, Goodpastures syndrome, and infections can cause glomerulonephritis, which can lead to kidney damage and failure. Learn about low creatinine levels., The body produces creatinine as a result of muscle function. Type III is necessary for the hollow points in your body like large capillary, the bowel and bladder. As we discuss later in the article, there are some instances where you should not take collagen due to kidney-related issues, but that has to do with your protein intake. Will they be normal? Creatinine is a byproduct of normal muscle function. They might also help to lessen wrinkles. Type I collagen is ounce for ounce more powerful than steel. Impact of Smoking and Alcohol Use on Facial Aging in Women: Results of a Large Multinational, Multiracial, Cross-sectional Survey. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715121/, Collagen and Sleep: Medical Hypotheses. (n.d.) Kidney Stones. https://www.kidney.org/atoz/content/kidneystones, Kidney Stone Treatment: United Kingdom National Health Service. Her work has appeared in publications such as, Ankylosing Spondylitis: Weve Got Your Back, Whats Next? Collagen is also produced naturally in the body by combining amino acids, the building blocks of proteins found in food. First, let's discuss our kidneys and what they do for our body. Effect of cimetidine on renal function in normal man. You can also buy vegan collagen powders made of bacteria and yeast. Doctors can test how much creatinine is in the blood to check kidney function. As a source of protein, collagen can help to increase energy levels and promote a healthy metabolism. Lytchett House, 13 Freeland Pk, Wareham Rd, Poole, Dorset, BH16 6FA, Copyright 2023 Vitalized Future | Bamboo on Trellis Framework by Mediavine. Especially if you have had a type of kidney stones known as calcium oxalate stones, its best to steer clear of collagen supplements. Kidney Int. Is there such a thing as too much collagen powder? Calcium. Meanwhile, if you notice any symptoms associated with kidney stonessevere pain on either side of your lower back or in your abdomen; nausea and vomiting; fever and chills; blood in the urine; or cloudy, foul-smelling urineor any other adverse side effects, stop any supplementation immediately and let your doctor know. If your kidneys aren't working well enough to remove toxins and waste from your body, you could notice a wide range of symptoms, including: Nausea. These are whats known as kidney stones.. So theres no guarantee that your collagen supplement contains the type or amount of collagen the label says it does. Chronic kidney disease; Collagen; Extracellular matrix; Renal fibrosis; Stem cells; Vascular calcification. Her work has appeared in publications such as Shape, Cosmopolitan, Well & Good, Health, SELF, Womens Health, Greatist, Bustle, and more. Each offering of VitaPost Collagen Complex gives replenishing hydrolyzed collagen. (Is It Safe? To be secure, its always a good idea to adhere to the dosage directions on your collagen supplement of option. eCollection 2022 Dec. Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways. Would you like email updates of new search results? It can be either acute, with symptoms that come on quickly, or chronic, with symptoms developing over time. Some medications can increase the level of creatinine on lab tests without actually hurting the kidneys. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638235/, Kidney Stones and Metabolic Disorders: Translational Andrology and Urology. While many supplements are helpful for those with kidney problems, there are some that should be avoided as well. While more men go bald, many women also have hair loss or thinning as they age. Bethesda, MD 20894, Web Policies Supplementing the diet regimen with hydrolyzed collagen has actually been connected with joint advantages for an entire range of individuals, from age-related joint degradation, to highly-active athletes who press their joints to the limit. As there are currently no studies, its unclear whether taking creatine and collagen together provides further benefits than taking them individually. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. If you're already at a high risk for developing kidney stones, collagen isn't recommended. Collagen supplements are not only helpful for your skin yet also for your hair, nails, and joints. In a healthy body, the kidneys filter creatinine from the blood and excrete it through the urine. FOIA Or, when you're low on calcium intake, they can also be excreted through the urine as dissolved calcium-oxalate. Collagen is the most abundant protein in the human body. In a study of older people, creatine improved the subjects memory and recall ability. A study of 30 people had all the subjects take 16g of collagen for 6 months. Moderate-intensity exercise (maintaining heart rate between 55% and 90% of maximum) may elevate creatine kinase (CK) to levels that meet the diagnostic criteria for rhabdomyolysis if the exercises involve eccentric muscle contractions, such as weight lifting or downhill running (strength of recommendation [SOR]: C, As we previously discussed, collagen is a protein, and therefore counts towards your daily protein intake. Improving Creatinine Levels. All rights reserved. Some medications can increase the level of creatinine on lab tests without actually hurting the kidneys. -, Humphreys BD (2018) Mechanisms of renal fibrosis. Levels should return to normal following treatment of the underlying issue. It can assist with joint pain and arthritis as well as making you feel a lot more vibrant. Semin Nephrol. Type I, which gives strength to your skin, bones, ligaments, and tendons, Type II, which makes up the flexible cartilage that helps support your joints, Type III, found in your internal organs, blood vessels, and muscles, Type V, which is present in your corneas as well as some layers of skin and hair, : Collagen Structure and Stability., : Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials., Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails, The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials., : A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study, Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men, Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women A Randomized Controlled Study, Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance., The Journal of Clinical and Aesthetic Dermatology, : A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair., : Decreased Collagen Production in Chronologically Aged Skin., : Collagen peptide supplementation in combination with resistance training, improves body composition and increases muscle strength in elderly sarcopenic men: a randomized controlled trial., : Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature.. Collagen is found in connective tissue, skin, tendons, bones, and cartilage. High intensity exercise can also increase certain blood biomarkers, including creatinine. Creatinine levels will usually return to normal when someone stops taking it. Interference by cephalosporins with creatinine measurement by desk-top analyzers. Collagen is a protein found in our bodies, and it is formed through chains of amino acids. PMC Under normal circumstances, and for those issues which collagen is known to help improve, too much collagen is not harmful. Collagen supplementation is healthy for most people but those who have conditions that impact the kidneys who should refrain from taking them, says nephrologist and functional medicine practitioner Majd Isreb, M.D., an assistant professor at Elson S. Floyd College of Medicine at Washington State University in Spokane. But other medications like certain antibiotics, heartburn medications, and cholesterol medications can simply change the results of the blood test. Accessibility Vervloet MG, Adema AY, Larsson TE, Massy ZA. Collagen protein supplements contain an amino acid called hydroxyproline, which the body metabolizes into oxalate, explains David P. Selzer, M.D., a nephrologist at NYU Langone Medical Associates in West Palm Beach, FL. Zhang X, Li Y, Yang P, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J, Chen M. Arterioscler Thromb Vasc Biol. The greater someones muscle mass, the higher their creatinine levels. According to the British Medical Journal, the usual reference range for serum creatinine is 60110 micromoles per liter (mcmol/l), or 0.71.2 milligrams per deciliter (mg/dl), for males and 4590 mcmol/l (0.51.0 mg/dl) for females. Some health conditions can also damage these organs, leading to increased creatinine levels. Some of these things may be just fine for you to take, and others may be potentially dangerous. https://www.hsph.harvard.edu/nutritionsource/collagen/, Collagen Decrease: The American Journal of Pathology. The past five years has seen increasing emphasis on the early detection and treatment of chronic kidney disease, together with reporting of estimated glomerular filtration rate (GFR) alongside serum creatinine values.