How is your puppy doing? Simparica and Simparica Trio are available by prescription only. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. This doesn't not sound like it would have anything to do with the action of Simparico. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. He wasnt throwing up at all until he received this medication. The flea components vary but having had one seizure you're now prone to being sensitive to even the "safer" ones. Then gave me pills of prednisone for him to take 1 pill twice a day . I am giving her supplements to support her heart and nerves and she's a little better each day. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Instead it has become a world of greed. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. I gave my six-year-old dog SIM perica because the combo guard was on back order. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. Use with caution in dogs with a history of seizures or neurologic disorders. Skin issues. - she's had several episodes since then. This medication must really be strong to do Flea tic and heart worm etc. It is better but not gone. She seems to have aged five years since T-Day. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. My 1.5 yr old German Shepherd was a happy, playful healthy dog until this Poison and now I blame myself for what she is going through. I feel so dumb for taking him off of something that we had no problems with and it worked fine, just to try something new that he didn't need. It was the first time she had taken Simparica. Also what are you looking at giving your dog as a seizure medication?? I hope this drug has not caused permanent damage. Gave my 14 month old 88 lb. I hope and pray for no long term affects. X-rays fine. Im worried sick. So new pup goes on garlic tabs-as he growing I'm upping the amount because I wanted him to be protected. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. So sorry! But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. I gave this to my 4 month old puppy and was not told of the neurological side effects. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. Please do NOT use it!! The initial trial had seizure results but supposedly only in dogs with seizure history. Seriously I have had the worse luck. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. thank you. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. I should have kept with my gut feeling about any of these oral meds. I paid $120 for 6 months of poison. After seeing his condition worsen, that night we took him to an after hours urgent care. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Thannks !! We had family in for the weekend and he was not himself. He scratched at them which made it worse. This past October he just wasn't the same. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. But unfortunately it's only a dog is the big Pharma tune. Two weeks after first simparica dose.parasites gone. UPDATE We had one normal day on Friday. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. Sorry but keeping it caged due to a suspected side effect is is uncalled for. The reason I had stopped it , I saw a Instagram where a girls dog took the. So sorry! My dog steadily went downhill after I gave her the first dose of simparica. Doing better now, 2 days later. Called Vet tonight and got a first appointment for tomorrow morning . Itching has decreased immensely. My 5 year old Bichon Frises, Ivy, was on NextGard for years. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. Does your do still have a cough? . She spent 4 nights at the University of Auburn emergency room and vet clinic. This is just another reason to follow your vet's recommendations for annual physical exams and tests. She seems more anxious now and really attached to hubby. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. I just hope he has a turn around . Then giving more drugs for itching. I should have know it was a sign when he spat it out. Ive read these stories and am also disgusted. She didn't make it to the next day and died overnight. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. I argued with the vet that this is poison and she said why would I give your dog poison? I just wish I could find a vet who honestly loves my animals as much as I do. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. What are the side effects of Simparica Trio Chewable Tablets for Dogs? Then I gave it to her again the 3rd month and the same thing happened. The following day he died. I even told them about the Simparica which they dont respond to. Idk what to do. Im switching back to the old stuff. . Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. The following day he would not even drink water. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. The very next day he had diarrhea, and had it for 6 days. Wonder why PetSmart offers this if there are so many concerns reported. This sounds so scary. Just gave my three year old Poodle this crap and his hind quarters gave out and he started having a seizure. . These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. I will not be continuing with this treatment. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? I called the owner of my puppy's mom and she told me that the mom NEVER eats that stuff. Today the seizure like attack happened even though he is on the steroids. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. The .gov means its official.Federal government websites often end in .gov or .mil. Good luck. Anyway, he prescribed him pain relief for 7 days. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! The vet suggested Simparico trio . As a Followup. Our boy Axel had been on Heartgard his entire life. This is terrible. She also started drinking excessively, and peeing in the house. On 08/06 she threw up. Why would he knowingly recommend this? We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. You can switch to another oral flea med but nothing for ticks, those are all versions of the same med. As per chewable tablets, this medicine is safe for all breeds of dogs. I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. In addition to the tremors, have you noticed any . Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. He has never done this, and when I heard it and woke up he couldn't stop. Thank all who have posted to bring this subject to light. I wish every one the best. The site is secure. Some pets fare better with topical solutions instead of chewables. That is the only thing that has changed in her routine. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. but wasnt allowed in with him. Vet trip and meds $400! He had an MRI and it came out good. Losing my Dolly devastated me and I wanted to warn others about Simparica but I got sick. Stressing out now. The costs associated with these two products are roughly the same. And a bit more stumbling. 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