ATTIA: But I think thats an interesting point. So the former is one molecule of something called glucose and one of fructose bound together. And Ive got her into it now. Incredible evidence in how it prevents neurodegeneration and basically all forms of chronic disease. About Community. Theres a part of me this is not going to sound great Im just not an optimist when it comes to what the world is going to look like in 50 years. So, the other night, Olivias like, Daddy, lets watch a movie. And were like, all right. But of course, we live in an environment where natural selection doesnt have the time to make modifications. And so many years later, as I began to actually understand the benefits of sleep, it stands alone as one of what I think of as one of the four or five pillars of longevity. pick up the tab to really finish it, because this is a multi-year experiment. But the point is, without making these proactive changes, they mightve lived only until 70. And even if there were such data, what data are there that this harm is caused by the glucose itself? Wouldnt you like to live longer? And its a finding that basically predicts early onset of cardiovascular disease, which shouldnt have been a surprise to me because the list of men in my family who have died of cardiovascular disease is pretty long. Dr. Attia received his medical degree from the Stanford University School of Medicine and trained for five years at the Johns Hopkins Hospital in general surgery, where he was the recipient of several prestigious awards, including resident of the year. Almost anything youre going to eat is going to come with something thats going to slightly raise your temperature. Theres one disease, which is not really thought of as a disease, but I think of it as a continuum that is the foundation upon which all of those sit. ATTIA: Well, I think theres something biologically interesting that happens in people when they have a kid, which is, they sort of realize their own mortality in a way. Workout and Diet. I think its worth understanding that a little bit. LEVITT: And so why? And this mutation actually is what saved our species, because if we didnt have the ability to go to a cold place like Europe and get fat in the fall by eating all of the fructose-rich berries, we wouldnt have survived the winters. So theres this molecule called adenosine. Youll have to wait until Wednesday for Dr. Peters definition of greatness, so for now, Ill leave you with one final piece of wisdom: There are people out there who have so many genetic things working against them, that theyll be lucky to make it to 80. So it becomes a way for us to recycle our dead or defective cells. I want to be able to hop over a three-foot fence. LEVITT: Yeah, for sure. Maybe it was partly the placebo effect of all your happy stories about it. Marion Nestle notes the Arnold's working relationship with a National Restaurant Association and the National Cattlemen's Beef Association consultant. from Stanford University and holds a B.Sc. So theyve either died a cognitive death which is to say their minds have become so dull that theyre really not able to be the people they wanted to be [or] their body has broken down so much that the things that once gave them so much joy, theyre deprived of or emotionally theyve become depressed. It promises to be one of the most important books you'll ever read." Steven D. Levitt, New York Times bestselling author of Freakonomics "In Outlive, Peter Attia explores the science of not just . His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease) while simultaneously improving healthspan (quality of life). Additionally, Dr. Peter is an advisor to and/or investor in the following companies: Dr. Peter has an impressive career, but hes an even more impressive person in real life! So you went to Stanford and got your medical degree there and then you did your residency at Johns Hopkins. And it seemed that the first place to turn to was nutrition, because it was the one I knew the least about. Attia speaks at the Ancestral Health Symposium in 2013, "A Manhattan Project To End The Obesity Epidemic", "Is it what we eat? You need to hit a local minima in life to make a change, if not an absolute minimum. in mechanical engineering and applied mathematics. We would like it such that, when you die, its really your first encounter with death of any form. , So the big three are, in order, atherosclerotic disease so thats vascular disease, meaning heart disease and stroke. And I think a lot of people get there eventually in life, but I would just say, dont be afraid of that type of exploration. Six feet versus two feet., And if you could now paint the boundary conditions of that universe with actual data, the next time a virus comes up, we would at least have boundary conditions to say, Oh, this virus looks most like this virus.. My guest today is physician Dr. Peter Attia. He also receives speaking honorariums from organizations, including hospitals and health-related businesses, when he is asked to speak on longevity, metabolic-related topics, athletic performance, and his personal experience working in medicine. document.getElementById( "ak_js_3" ).setAttribute( "value", ( new Date() ).getTime() ); This field is for validation purposes and should be left unchanged. Stay tuned for Wednesdays episode Part 2 of my interview with Dr. Peter Attia! ATTIA: I actually this is probably one that has changed less than most in the past decade. Weve developed treatments for all kinds of conditions from acne to cancer, and weve greatly expanded our lifespans. Dr. Peter Attia is a physician focusing on the applied science of longevity. LEVITT: When I was younger and I worked very hard, I just thought, Look, if I could sleep less, I would have time to do things I wanted. And so I read the literature and I embarked on a sleep experiment. The heart could use it. It also impairs senescent cells or more likely impairs the secreting factors that are made by senescent cells. Its the cognitive piece so how well does your brain work as you age? And when I was applying for my first grant, I went to the senior people around the M.I.T. However, theres one disease that underlies all three of these. We can be reached at radio@freakonomics.com. So how about nicotine? scan a couple days later. I just didnt care if I was alive or dead, even though I wasnt even particularly tired. Dr. Peter is the perfect person to talk to about health and longevity, and Im excited to have him on. Dr. Peter Attia is a medical doctor specializing in health, longevity and preventive medicine. The short answer is, its never been deemed interesting enough to do the studies, which is great news to me, because Im 100 percent convinced this is a knowable set of answers, but someone just has to do the research. We certainly didnt learn anything about it in med school. on their work. LEVITT: All right, so lets talk about your very unusual background. So theyve either died a cognitive death which is to say their minds have become so dull that theyre really not able to be the people they wanted to be [or] their body has broken down so much that the things that once gave them so much joy, theyre deprived of or emotionally theyve become depressed. Its also that it has no fiber left in it as well. ATTIA: No, I think its the hardest job. Sleep supplement. I rarely have a conversation with Peter in which he doesnt introduce me to something Ive never thought about before. The only sad part is my dad said a few days ago, Yeah, the last person I grew up with and I was friends with, they died. Here we fans discuss the cutting edge of longevity science, the latest episodes, and anything we'd like to see/feedback for the future of the podcast. And my glucose level is very low. LEVITT: So you love your children with a depth that is rare and I admire. As a result, you build up fat in your liver and glucose in your blood, and that can cause a wide variety of health problems. You got to do it.. In other words we have to learn how to manage the causes of stress and anxiety in our lives. According to his website, Attia is "a Stanford/Johns Hopkins/NIH-trained physician focusing on the applied science of longevity, the extension of human life and well-being." These credentials have given Attia unparalleled clout (along with David Sinclair) in this niche of influencers. Ive been enjoying them very much, If you want to know how to live longer, and how to live better, you should be listening to Peter. ATTIA: I think without a step-function change in our technology and our understanding of science, it probably depends on how bad they are to begin with. ATTIA: I dont know if that exercise did, but yes, I think a lot of the training that I did did pay off, actually. LEVITT: Well, it sounds like you ended up making the right career choice. for Dr. Peters definition of greatness, so for now, Ill leave you with one final piece of wisdom: There are people out there who have so many genetic things working against them, that theyll be lucky to make it to 80. is directly causal in disease in nondiabetics; There have been no RCTs demonstrating that better glycemic control in nondiabetics leads to better outcomes, much less using CGM; There have not been any long-term studies using CGM in nondiabetics whatsoever; Some of the interventions to reduce CGM readings (say, carbohydrate restriction) also would increase postprandial triglycerides, also associated with worse outcomes; There is therefore an unclear tradeoff between hyperglycemia and hypertriglyceridemia, and that is assuming that they are each causal for bad outcomes in healthy nondiabetics; The cutoffs for unacceptable glucose excursions by Peter Attia are not based on any evidence whatsoever and are arbitrary. Pacific Standard", "Blaming the Patient, Then Asking Forgiveness", "Silicon Valley Wants to Cash In on Fasting", "Attia P. TED: Is the Obesity Crisis Hiding a Bigger Problem? ATTIA: No. Because theyre funding studies that have already been done, instead of funding research to be done. When it comes to reversing the effects of Type 2 diabetes and preventing further chronic health problems, sleep is essential. But not too far behind it is cancer. LEVITT: I will say that youve taught me a lot and I never told you this before youre one of the few people on the planet whose opinion I trust so completely that when you tell me to do something, no matter how absurd it sounds, I do it. And I think its the perfect model, which is: let the government come in when its been de-risked. And finally, the fourth thing that significantly affects our chances of getting Type 2 diabetes is stress. ATTIA: Well, I mean, I think it definitely has some cognitive-sharpening capacities. Thats a relevant detail that Im sure a few peoples eyes just rolled back in their head. Im afraid that Ive worked too much. today! And a guy who was one weight class above me and quite frankly, at that point, a better fighter I mean, he just landed a right cross on the side of my head that at the time, I didnt think anything of. What did your day look like? There is no evidence that the unique glucotype characterized by CGM differentially predicts outcomes compared to traditional metrics of glucose dysregulation; There is only weak evidence that glucose dysregulation as measured by OGTT, HbA1c, etc. Anonymous comments will be deleted. In addition to training at Johns Hopkins Hospital, Dr. Peter also spent two years at the National Institutes of Health as a surgical oncology fellow at the National Cancer Institute, where his research focused on immune-based therapies for melanoma. With over 50 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimers disease, cancer, mental health, and much more. I actually find a fasting sleep to be some of the most amazing because Im watching this plummeting temperature, rising heart rate variability, falling heart rate, all of those really valuable things. , I think there [are] basically three ways that we can approach dealing with this: One of these is through psychotherapy, pharmacotherapy, and then behavioral therapy, which Im an overwhelming proponent of in particular a type of behavioral therapy called Dialectical Behavioral Therapy or DBT. , My training is very specific, but now it is fundamentally organized around four pillars: Stability, strength, mitochondrial or aerobic efficiency, and anaerobic performance. , Those four main pillars focus on the different areas Dr. Peter wants to maintain good health even into old age. December 9, 2022, Designed by Elegant Themes | Powered by WordPress. 200mg is relatively minor, but he supplemented for the sake of avoiding muscle cramps. But we just have to know what were doing it for and what matters. So, for example, if the argument is that the people who are most disadvantaged genetically will have the greatest benefit from change, the number I talk about with patients is probably five to seven years. I would be up at five oclock every morning. So thats how I ended up at McKinsey. Im sure anyone who did something at a high level, whether it be playing the piano or doing anything, once theyre so far past their prime, they look back and go, I dont think I appreciated what it took to get there.. And caffeine blocks that. Lets dive in! By reducing the amount of carbohydrates we consume and by exercising, we reduce the amount of glucose were consuming and increase our muscle so that when we, consume glucose, our bodies have somewhere to put it. But something inside said, You dont feel right. So I said, Hey, Mike, I got to call it a day, man. And when I went down to cool down by hitting the speed bag, which is that tiny little round bag that basically has no weight or impact just the impact of hitting that hurt my head so much that I was like, I got to stop.. And we might have to take a closer look at your sleep habits. Dr. Attia is a huge proponent of supplementing with magnesium. Every time I go to an academic seminar, Im going to bring two pieces of Nicorette gum. Learn how to live longer, be healthier, and optimize your performance. Hes playing the long-game and working hard to maintain the strength and overall good health hell need to continue living an active and fulfilled life even when hes over 100 years old. Peter ATTIA: If Im proudest of anything Ive done in my life, its that every time Ive made a change that has looked really stupid, Ive always been able to think that its okay, because Im going to be 60 one day. It was about 10 things. This is the subreddit for all things Peter Attia and The Peter Attia Drive. Have any hacks how to do? If you want pasta sauce, find one that has no sugar. And I now realize in retrospect that was almost assuredly primarily being contributed by the lack of sleep. degrees in mechanical engineering and applied mathematics. He is the host ofThe Drive, one of the most popular podcasts covering the topics of health and medicine. Peter Attia has dedicated his medical career to investigating the relationship between nutrition, obesity and diabetes. LEVITT: No, it was when I worked in consulting. And then take a little step further, and you reach neurodegenerative disease, of which Alzheimers disease is far and away the most common and also the most rapidly increasing. LEVITT: Yeah, absolutely. what happened to peter attia. But its something I at least pay attention to now. What happened to @DMSabatini. My Centenarian Olympics has 18 events in it. Now hes a physician focused on the science of longevity. ATTIA: So ketosis is arguably one of the most important, if not the most important, metabolic adaptation that allowed our species to survive, because our brains are so dependent on glucose. And you would say, Peter, those seem really easy, and youd be right as a 37-year-old stud, but the point is most 60 year olds couldnt do them. Dr. Peter Attia. And then I was going to Netflix to find it. I think there [are] basically three ways that we can approach dealing with this: One of these is through psychotherapy, pharmacotherapy, and then behavioral therapy, which Im an overwhelming proponent of in particular a type of behavioral therapy called Dialectical Behavioral Therapy or DBT. Dr. Peter Attia. Because what youre basically saying is: whats the dose? And I missed that routine once in four years. Comments requesting medical advice will not be responded to, as I am not legally permitted to practice medicine over the internet. So thats called starvation ketosis. Its the common factor behind all three biggest causes of death Type 2 diabetes. Peter Attia is a physician focusing on the applied science of longevity. ", https://en.wikipedia.org/w/index.php?title=Peter_Attia&oldid=1139971534, Stanford University School of Medicine alumni, Articles with unsourced statements from February 2023, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 17 February 2023, at 19:54. So, if we can stop eating a few hours before bedtime, well get better sleep, our bodies will process the glucose we consume, and we can avoid Type 2 diabetes. Why werent we immediately engaging in a whole bunch of experiments that would very rapidly get us answers to questions that would enable us to decide what to do? All of the music you heard on this show was composed by Luis Guerra. So, yeah, I definitely lost a lot of I.Q. Apparently Peter and his buddy Gary Taubes just love themselves some crappy pseudoscience. LEVITT: The set of things hes done to his body over time, in the spirit of self-experimentation, are mind-blowing. And then youd just be guaranteed to get N.S.F. But a quick 20-minute power nap is no big deal! But I think there was a very similar insecurity. We care about this. And better? So autophagy is a very important process for preventing cancer. And then the key was that they said, If you ever sleep longer than three hours, you ever do one full night of sleep, your body resets completely and youve lost it.. ", "Are We Fighting The Wrong Battle In The Obesity War? Additionally, Dr. Peter is an advisor to and/or investor in the following companies: Virta Health, Hu Kitchen, Oura Health Oy, Magic Spoon Cereal, Inevitable Ventures, Salutoceuticals, Dexcom, and Supercast. I look at my father, whos 86 and still runs and still practices medicine full time, and we do trivia contests together and hes still as good as he ever was. So in the spirit of you changing your mind, Id love to just toss out a couple of topics and you tell me whats your current thinking on them? Youre listening toPeople I (Mostly) Admire with Steve Levitt, and his conversation with physician and scientist Peter Attia. Fasting turns on a process called autophagy. So, nicotine leads to the up-regulation of an enzyme I wont bother to name that is beneficial to how the muscles can utilize fat for energy and how the fat cells refrain from just taking more fat in as storage. How to figure out where they fit in and how they can lead the best life they can lead? Note this may include abusive, threatening, pornographic, offensive, misleading or libelous language. LEVITT: Yeah. His unique spectrum of experience, relentless obsession over details, and ability to translate the cutting edge of science into something the rest of us can use is invaluable., Ive always been fascinated with medicine. And to me, we want to minimize that gap, right? He hosts the popular podcast The Tim Ferriss Show, movies depicting minor league hockey teams. ATTIA: Exactly. Thats the ultimate goal: To practice medicine and healthy living in such a way that we avoid encountering any kind of death before we have to. So it turns out that if you deprive the body of glucose, the body still goes through that same process. Yeah, some days its just fun to sit there and laugh and goof off. He is the host of The Drive, one of the most popular podcasts covering the topics of health and medicine. And more recently, and that is to say in the last hundred years or so, people figured out that you could basically trick your body into doing that by restricting carbohydrates. ATTIA: Well, I think the benefits of fasting are legion. Theres days I guess I am. Science has proven time and again that staring at screens right before bed can drastically reduce our sleep. I think nicotine is a remarkable molecule. Were not talking about inoculating someone with hepatitis or H.I.V. I would run between five and 13 miles each morning. Apparently Peter and his buddy Gary Taubes just love themselves some crappy pseudoscience. And it was at that point that I learned about this company called McKinsey that was like business school that you got paid for. Prior to that, in 1996, he received a Bachelor of Science degree in Mechanical Engineering and Applied Mathematics from Queen's University. Residency didnt seem very merit-based. One half of all Americans are on that spectrum. Dr. Peter Attia. So they think that you can show them something you havent done when youre done. So when you contrast living to 70 [and] spending 20 years in misery versus living to 75 with maybe two years in misery, it just doesnt even strike me as a trade-off. . They get their money from Congress. When we start to experience those mental health issues, we die in a sense. 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