Biosplice Therapeutics, Inc. (formerly Samumed, LLC) is a private biopharmaceutical company based in San Diego, California.It was founded in 2008 by Osman Kibar.. Samumed's products in development target novel components of the Wnt signaling pathway. Ikena has entered into a global strategic collaboration with Bristol Myers Squibb on the IK-175 and IK-412 programs. Michael White, Ph.D. joins Samumed as Chief Scientific Officer, Samumed Taps Pfizers Michael White as Its Chief Scientific Officer, Samumed Publishes Unique Mechanism of Action for SM08502 in Targeting Gastrointestinal Tumors, Samumed Announces Publication of Preclinical Data Demonstrating That SM07883 is a Potential Treatment for Alzheimers Disease, Samumed Launches Phase 3 Lorecivivint (SM04690) Clinical Program in Knee Osteoarthritis, Samumed Announces Positive End-of-Phase 2 Meeting with FDA for SM04690 in Knee Osteoarthritis. Amarin announced Tuesday that shareholders voted in line with what Denners biopharma VC Sarissa Capital wanted, electing all seven of Sarissas nominees to Amarins board of directors. Media Contact: Andrea Sampson, Sampson PR Group asampson@sampsonprgroup.com, 562-304-0301 Investor Contact: Jody Cain, LHA Investor Relations Jcain@lhai.com, 310-691-7100 If you're already an Endpoints subscriber, enter your email below for a With their platform's origins in small molecule-based Wnt pathway modulation, they develop therapeutics to address a range of degenerative diseases, regenerative medicine, and oncology. Other biopharma companies will soon make their debut on stock exchanges. BioSplice Therapeutics . So they plan to test it in patients with mismatch repair mutations, so the tumors are already making mutations. In addition, we expect to realize the tremendous potential of our oncology program, as well as neurology and other areas of significant unmet need., Joy Ghosh, PhD, of Eventide Asset Management, added, Biosplices alternative splicing platform has enormous potential to address critical needs in osteoarthritis, oncology and neurology, among others. Biosplice's drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimer's disease to. After about two or three hundred failures, Langers team had already proved the idea could work in a 1976 paper published in Nature. Biosplice's mission is to restore health by delivering first-in-class therapies that harness alternative splicing. About Biosplice Therapeutics Stock Samumed is in the medical research and development for tissue-level regeneration. Keith Speights: Now, there have been several IPOs of biotech stocks recently, and a few more are on the way. Learn more about how to invest in the private market or register today to get started. The Motley Fool has a disclosure policy. 308 followers 310 connections. Among its financial backers are Hercules Capital, Invus, and Arch Venture Partners. With their platform's origins in small molecule-based Wnt pathway modulation, they develop therapeutics to address a range of degenerative diseases, regenerative medicine, and oncology. Finances from the IPO, as well as the cash from the Series B, will be used to develop treatments for nucleotide repeat expansion disorders, including its lead program in Friedreich ataxia, which is expected to enter clinical development in the first half of 2022. Nothing in the Website should be construed as being financial or investment advice. The biotech boom in the early days of the pandemic helped fuel the rise of Taysha Gene Therapies and Jaguar Gene Therapy, but the winter freeze that followed has also caused a hunkering down for the biotechs, chaired by ex-AveXis CEO Sean Nolan. SAN DIEGO and CHENGDU, China, Sept. 15, 2021 -- Biosplice Therapeutics, Inc. , a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major. Register today to connect with our Private Market Specialists and learn more about new pre-IPO investment opportunities. For the brain cancer data, it looks pretty good in extended survival over placebo. Any securities offered are offered by Forge Securities LLC, a registered Broker Dealer and member FINRA / SIPC. To make the world smarter, happier, and richer. Here are similar public companies: HealthStream (NAS: HSTM), Doximity (NYS: DOCS), Zymergen (NAS: ZY), Sight Sciences (NAS: SGHT). The malignant cells permeated his bones, kidney, lungs and liver, and in December, his oncologist told him there was no point in continuing chemotherapy treatment. The stock will open this morning at $20 per share, which is on the upper end of what the company projected. In January, the company secured $120 million in a Series B financing round. Ikena Oncology is advancing five clinical, preclinicaland discovery programs. Anytime we're talking about extended survival, that's the gold standard for cancer. Merck has been looking to get its blockbuster drug Keytruda into earlier lines of treatment, and one of its latest trial results has the anti-PD-1 antibody moving firmly in that direction. Tags Biosplice Therapeutics oncology clinical trials cirtuvivint alternative splicing CLK/DYRK pre-mRNA splicing NSCLC CRC CRPC. Biosplice Therapeutics is in the medical research and development for tissue-level regeneration. Alternative splicing regulates genome potential by differentially joining or skipping gene segments at alternative splice sites. Biosplice's drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimer's disease to. The German tech investor Kizoo Ventures is committing 300m of its own cash to biotech start-ups working on rejuvenation and healthy lifespan expansion. We are particularly excited by lorecivivint, which has the potential to be a first-in-class medicine that could confer both symptomatic and disease-modifying benefits to hundreds of millions of osteoarthritis sufferers worldwide.. Investors in this latest round comprise Eventide Asset Management, aMoon, SymBiosis II, Sands Capital, Verition Fund Management and others, and also includes existing investor support. In finance, a unicorn is a privately held startup company with a current valuation of US$1 billion or more, across technology centers throughout the world.. San Diego, California, United States. Last years list profiled 15 leaders and included a swath of the industry, such as repeat biotech founder Carolyn Bertozzi, minted as a Nobel laureate just months later. The resulting proteome diversification is a fundamental physiological aspect of tissue fate and function. These include SPF , Google Universal Analytics , and Domain Not Resolving. Unlock this story instantly and join 161,500+ biopharma pros reading Endpoints daily and it's free. Based in San Diego, CA, Biosplice is developing small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. The stock will open this morning at $20 per share, which is on the upper end of what the company projected. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA. Investing in private companies may be considered highly speculative and involves a high degree of risk, including the risk of substantial loss of investment. They say they will not only cure arthritis, but also cancer in the future with their amazing technology. Funds from the IPO and the Series B will support development of the companys oncology pipeline. Internal digital and data science expertise is critical to developing a united value proposition that aligns the benefits of the digital and medicinal product. CRISPR is a pair of biological scissors that can cut and replace genes in cells and living organisms which can open up the potential to cure genetic diseases and perform DNA-based diagnostics. Learn More. In January, Ikena announced IK-930, a TEAD inhibitor targeting the Hippo signaling pathway, has entered IND-enabling studies. Biosplice Therapeutics (Excluding its subsidiaries) has filed 96 patent applications at USPTO so far (Excluding Design and PCT applications). Funding Rounds Number of Funding Rounds 5 When developed in combination with a medicinal asset, digital therapeutics enable significant market differentiation and significant benefits for stakeholdersfrom optimizing patient outcomes to supporting more efficient generation of compelling real-world data Your use of the Website and your reliance on any information on the Website is solely at your own risk. Biosplice Therapeutics (formerly Samumed) "Biosplice's mission is to restore health by delivering first-in-class therapies that harness alternative splicing.". Log in. Making the world smarter, happier, and richer. We are delighted to align with our new investors and board behind the immense therapeutic potential of Biosplice, said Cevdet Samikoglu, Chief Executive Officer of Biosplice. In September 2020, Sorrento Therapeutics released positive Phase 1b trial data (clinicaltrials.gov NCT03542838) of resiniferatoxin (RTX) in the reduction of OsteoArthritis (OA) knee pain. Take like 20mg of zinc that will help reduce the massive prolactin spike that causes the itch. For decades, MIT professor Robert Langer believed scientists could deliver large molecules such as RNA through tiny particles to treat a range of diseases. Integrating digital therapeutics early in the asset development process will allow for gathering of clinical data to drive a clearer value proposition that maximizes the potential of both products Registering gives you access to one of our Private Market Specialists who can guide you through the process of buying or selling. Merck revealed on Wednesday that a Phase III trial investigating Keytruda for patients with stage II, IIIA or IIIB non-small cell lung cancer hit its event-free survival primary endpoint. Copyright 2023 Forge Global, Inc. All rights reserved. The company is developing a platform of gene-targeted chimera small molecules for the treatment of serious degenerative disorders caused by inherited nucleotide repeat expansions. Alfredo Naj Domingos prostate cancer was spreading. Biosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. For decades, MIT professor Robert Langer believed scientists could deliver large molecules such as RNA through tiny particles to treat a range of diseases. Pretzel Therapeutics Launches with $72M to Advance Mitochondrial . www.biosplice.com Formerly Known As Wintherix & Epitherix, Samumed Ownership Status Privately Held (backing) Financing Status Private Equity-Backed Primary Industry Drug Discovery Other Industries Biotechnology Pharmaceuticals Primary Office 9360 Towne Centre Drive San Diego, CA 92121 United States +1 (858) 000-0000 Biosplice, a former anti-aging unicorn, slashes staff in latest episode of its long fall from grace Kyle Blankenship Anti-aging startup Biosplice has had quite the downhill stumble after. Investing in private companies may be considered highly speculative and involves high risks including the risk of losing some, or all, of your investment amount. Early market entry is fundamental, and manufacturers must plan strategically to consider how digital therapeutics (DTx) are best incorporated into the launch and go-to-market strategy. Content on the Website is provided for informational purposes only. Omega Therapeutics of Cambridge, MA completed their initial public offering (IPO) two weeks ago and is now publicly traded on Nasdaq. Tom Jones take zinc after sex or personal release. SM04554 Disappears From Biosplice's Website (9/7/21) . Price as of February 28, 2023, 4:00 p.m. The company is developing a novel therapeutic platform called "Omega Epigenomic Programming", which involves a new class of DNA-sequence-targeting . Maybe the next best thing is to have big pharma partners endorsing its drugs. https://www.streetinsider.com/Globe+Newswire/CIO+Leadership%3A+Opportunities+for+Female+Tech+Leaders+to+Foster+Employee+Mentorship+and+Sponsorship+to+Strengthen+Inclusivity+and+Engagement+Will+Drive+the+Dialogue+at+the+2021+HMG+Live%21+Global+Women/19037221.html, https://seekingalpha.com/article/4456091-week-in-review-everest-announces-2-in-licensings-with-value-of-1-billion, https://www.benzinga.com/pressreleases/21/09/g22950166/biosplice-licenses-development-and-commercialization-rights-for-lorecivivint-a-novel-phase-3-osteo. EDG-5506 is currently being assessed in a Phase I study. Please note this link is one-time use only and is valid for only 24 hours. Novartis can't make enough of it, Decades after breakthrough, scientists still puzzling over mRNA delivery, Following the government's lead, Lilly caps out-of-pocket costs for insulin at $35 per month, A gene editing 3.0 player goes deep on cash, frontier science to put precision epigenetics to the big test, Ex-AveXis crew trims staff at Chicago-area Jaguar Gene Therapy, Alex Denner secures victory in Amarin vote, ousting chair and adding supporters to board, Whos charting paths for LGBTQ+ leaders in biopharma? Under no circumstance shall we have any liability to you for any claims, loss, damage or expenses of any kind arising, out of or in connection with your use of the Website or your reliance on any information provided on the Website. Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. CARGO Therapeutics will enter a Phase II trial later this year with the goal of taking its autologous CD22-targeted CAR-T cell therapy to the FDAs doorsteps for an approval in large B-cell lymphoma. Biosplice Therapeutics, Inc. Say they will Not only cure arthritis, but also cancer in the future with amazing... //Seekingalpha.Com/Article/4456091-Week-In-Review-Everest-Announces-2-In-Licensings-With-Value-Of-1-Billion, https: //seekingalpha.com/article/4456091-week-in-review-everest-announces-2-in-licensings-with-value-of-1-billion, https: //www.benzinga.com/pressreleases/21/09/g22950166/biosplice-licenses-development-and-commercialization-rights-for-lorecivivint-a-novel-phase-3-osteo lifespan expansion # x27 ; s mission is restore... Construed as being financial or investment advice published in Nature to Advance Mitochondrial caused by inherited nucleotide repeat.... And data science expertise is critical to developing a united value proposition that aligns the benefits the! 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